Yes, assuming of course that your load develops enough velocity at the muzzle. Although this is usually no problem with barrel lengths of six inches or more, just don’t expect the same type of performance from a 2 1/2” snubby. If you’re dealing with muzzle velocities of 1000 fps or higher, this bullet will give good performance. It has a jacket and core that are designed to expand even at velocities as low 800 fps. Since the remaining velocity at 100 yards will be well above this, expansion will be reliable at any practical handgun range.