No, not when using propellants fast burning powders such as Bullseye, 231, or Unique. This is especially true when using larger cases that were originally intended for black powder, like the .44 Special or the .45 Colt. This is just a function of the powder’s burning rate and bulk density, and is not an unusual situation.
Do I need to be concerned about the air space between the bullet and powder when using powders like Bullseye?
Sierra Bullets > FAQs > Do I need to be concerned about the air space between the bullet and powder when using powders like Bullseye?